新加入上海科技大学生命科学与技术学院的李夏军研究组拟招聘一名博士后。本研究组主要研究遗传学和表观遗传学，干细胞和发育生物学。我们的实验室发现跟印记基因调控有关的主要因子ZFP57 (see Dev. Cell 15, 547－557)。我们第一次在哺乳动物里发现母本和合子的功能同时缺失导致胚胎死亡的现象。我们的论文已被引用300多次。在此基础上我们研究了ZFP57在小鼠胚胎，胚胎干细胞和诱导干细胞里维持印记基因正常表达的作用。近来我们发现ZFP57母本和合子的功能也维持印记基因在心脏里的正常表达 (see PNAS 112(16): E2020-9)。ZFP57的缺失影响重要的NOTCH信号传递和心脏发育。希望更详细了解我们工作的申请人请查看李夏军实验室在美国西奈山医学院的网页：http://icahn.mssm.edu/profiles/xiajun-john-li 

一、岗位职责：
       1) 独立承担部分实验室的研究项目并参与指导研究生的日常研究工作；
       2) 协助PI处理研究相关事务，包括实验室日常管理和维护，基金申请，项目相关的业务委托与合作交流。 

二、应聘条件： 

1） 具有生物学有关专业的博士学位或即将被授予博士学位。 

2） 应有扎实的遗传学，表观遗传学，分子生物学，细胞或发育生物学研究基础。 

3） 有端正的工作态度和认真负责的工作精神。 

4） 有良好的英语基础。 

     上海科技大学提供良好的工作环境和生活待遇。请感兴趣并符合这些条件的申请人通过人才招聘系统（http://jobs.shanghaitech.edu.cn/）提交应聘申请，或将个人中、英文简历发到: slst@shanghaitech.edu.cn, 邮件标题注明：应聘某某岗位+本人姓名+中国博士人才网抄送：XL-2016@qq.com。请同时提供三个熟悉你的推荐人的名字和通讯方式（包括电话号码和电子邮箱）。 

Research Summary 

The Li lab is interested in epigenetic regulation in stem cells with focus on genomic imprinting. Our lab discovered Zfp57 as a master regulator in genomic imprinting. Zfp57 is a maternal-zygotic effect gene and loss of Zfp57 causes maternal-zygotic embryonic lethality, the first one identified in mammals. Recently, we found both maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development.

Genomic imprinting is absolutely essential for mammalian development. Dysregulation of genomic imprinting causes a variety of human diseases including cancer, diabetes, cardiovascular diseases and neurological disorders. We are interested in modeling human diseases by utilizing Zfp57 mutant mice that we have generated previously. In addition, we will analyze the functions of Zfp57 in maintaining genomic imprinting in ES and iPS cells. Since genomic imprinting has been found to be unstable in these stem cells and loss of genomic imprinting will result in many human diseases, our research may lead to the strategies for derivation of ES and iPS cells with proper genomic imprinting that are suitable for future therapeutic applications.

Selected Publications: 

Lau H., Liu L. and Li X. (2016). Zfp57 mutant ES cell lines directly derived from blastocysts Stem Cell Research 16: 282-286.

Shamis Y., Cullen D., Liu L., Yang G., Ng S-F, Xiao L., Bell F., Ray C., Takikawa S., Moskowitz I., Cai C., Yang X. and Li X. (2015). Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development. Proc Natl Acad Sci U S A 112(16): E2020-9.

Takikawa S., Ray C., Wang X., Shamis Y., Wu T. and Li X. (2013). Genomic imprinting is variably lost during reprogramming of mouse iPS cells. Stem Cell Research 11(2): 861-873.

Li X. (Invited paper) (2013). Genomic imprinting is a parental effect established in mammalian germ cells. Current Topics in Developmental Biology. 102:35-59.

Zuo X., Sheng J., Lau H., McDonald CM, Andrade M., Cullen DE, Bell FT, Iacovino M., Kyba M., Xu G. and Li X. (2012). The zinc finger protein ZFP57 requires its cofactor to recruit DNA methyltransferases and maintains the DNA methylation imprint in 
embryonic stem cells via its transcriptional repression domain. J. Biol. Chem. 287(3): 2107-18 (Epub 2011 Dec. 5)  (Highlighted in ESC &iPSC News, Top Story from Whitehead Institute).

Li X. *, Ito M., Zhou F., Youngson N., Zuo X., Leder P. and Ferguson-Smith, A. (2008). A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints. Developmental Cell 15, 547-557 (*, sole corresponding author) (Previewed in Developmental Cell 15: 487-8, 2008). 

Postdoctoral Associate position available: 

The candidate must have a doctoral degree (PhD or MD) and has had strong previous research experiences in genetics, epigenetics, molecular biology, cell biology or developmental biology. ShanghaiTech University provides excellent working and living environment, with very competitive stipend. Please send your CV, together with the contact information of three referees who know you well, to the following email address: XL-2016@qq.com 

来源：

http://jobs.shanghaitech.edu.cn/job.asp?id=408