The Levy Laboratory is the focal point of the Precision Vaccines Program at Boston Children’s Hospital/Harvard Medical School. The Program employs cutting edge technologies to understand age-specific features of immune responses to inform development of vaccines tailored for optimal safety and immunogenicity towards distinct populations. Due to distinct immunity, most infection-induced death occurs at the extremes of life motivating development of improved vaccines that are safe and effective in the young and old.
We seek a skilled and motivated post-doctoral scientist with background in Immunology (experience in T and B lymphocyte studies a plus), Vaccinology, and/or Systems Biology and Bioinformatics to lead projects employing human and/or murine immunologic assays and systems biology to characterize age-specific vaccine responses and development of novel adjuvanted vaccines. The project will employ recent knowledge in the areas of innate immune pathways (TLRs/inflammasome), small molecule screening, and nanoparticle technology to identify adjuvants and enhance immune responses of those at the extremes of age in vitro and in vivo. Studies will employ in vitro modeling of human newborn, adult and elderly antigen-presenting cells, T and B lymphocytes as well as in vivo animal and human studies. Our laboratory, comprised of 12 current members including post-doctoral scientists, clinical fellows and technicians, is dynamic, international, mutually supportive and productive. We are well funded by NIH, Gates Foundation, internal support as well as multiple sponsored research agreements.
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