Job Description
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POSTDOCTORAL POSITION available to study PROGRAMMED DNA ELIMINATION. Programmed DNA elimination is a developmental process in which portions of the genome are reproducibly eliminated. This process occurs in diverse eukaryotes ranging from single-celled ciliates, nematodes, and crustaceans to birds and jawless fish (lampreys). In some nematodes, ~15% of the genome is eliminated in the somatic lineages during the 3rd through 5th cleavage (4 to 16 cell stage), while the germline genome remains intact. ~1000 germline and early development expressed genes are eliminated. Chromosomes break, regions are lost, and new and increased numbers of chromosomes are formed. Areas under investigation include analysis in nematodes of 1) how genome regions are marked for retention or elimination, 2) how break regions are identified and the mechanism of chromosome breaks, 3) how eliminated chromosome regions are selectively lost from holocentric chromosomes, and 4) the contributions of epigenetic factors including histone modifications and non-coding RNAs to DNA elimination. For additional information on the laboratory's research and recent publications, see http://140.226.65.22/Davis_lab/index.html The University of Colorado School of Medicine is located in a brand-new, state-of-the-art facility on the Anschutz Medical Campus. The Department of Biochemistry and Molecular Genetics provides an exciting, interactive and collegial scientific environment and is implementing a new RNA Bioscience Initiative (www.rnabio.co/) that is recruiting faculty, postdocs, and graduate students. Denver, CO is an affordable multicultural, metropolitan city. The nearby Rocky Mountains offer a spectacular scenic backdrop and an array of outdoor recreational opportunities within a 15-minute to two-hour drive from Denver. The climate in Denver is relatively mild and dry, and Denver boasts over 300 days of sunshine per year! Winters are mild, with average daytime highs of 45 degrees; summers are warm and dry, with average daytime highs of 85 degrees. Applicants must be curious, highly motivated, have demonstrated the ability to design and carry out creative, independent research, and have excellent communication skills using the English language and demonstrated scholarship through publication in internationally recognized English language journals. |
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