Description
Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.Summary/Scope
- The candidate will be responsible for developing research projects aimed at identifying mechanisms of regulation of genes involved in neurodegeneration and neuroinflammation.
- In particular the candidate will have the opportunity to define the effect of physiologic stress on translation of genes that drive neurodegeneration and determine the genes that regulate this process.
Responsibilities will include, but are not limited to, the following:
Investigation of the role of 5 regulatory sequences on translation under conditions that model neuroinflammation and neurodegeneration. Develop high throughput genetic screens to identify regulators of disease-associated gene expression under conditions of cell stress. Carry out genome scale loss of function and gain of function screens for modifiers of expression of genes under conditions mimicking those encounter in neurodegenerative disease.
Skills/Knowledge Required:
- Candidate should have a Ph.D. and extensive lab experience in molecular biology and mammalian cell biology.
- Experience in reporter gene assays, signal transduction studies, high content analysis, small molecule or functional genomics would be very helpful.
- Interest in neurodegeneration, inflammation, and or high throughput functional screening approaches.
Note: Postdocs will be eligible for Celgene benefits but will not be entitled to receive Celgene equity, bonuses or annual merit increases. Minimum relocation assistance will be offered on a case by case basis only.
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Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.
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