Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.
Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries - and growing we look for talented people to grow our business, advance our science and contribute to our unique culture.
The Translational Development/Pharmacogenomics group is seeking a post-doctoral candidate with a strong background in immunology and inflammatory diseases. The candidate will have a strong background in immunology, preferably with experience studying human immune biology. In addition to being suitable for publication, the work will involve understanding the key mechanisms that drive human immune disease, leading to drug target identification and validation, as well as understanding patient response to therapy.
Responsibilities may include, but are not limited to, the following:
1. Isolate peripheral blood cells from human blood donors. Isolate cells from tissue of various sources. Culture in different immune biasing/polarizing conditions.
2. Characterize altered immune responses relevant to disease. Perform flow cytometry characterization, sorting and gene expression analysis.
3. Coordinate the generation of gene edited cell lines, siRNA, and/or small molecules to develop tools for the study of loss-of-function of key targets in the setting of primary immune cells.
4. Maintain well written and accurate research electronic notebook detailing work undertaken
5. Comply with laboratory safety procedures
6. Publish findings in peer-reviewed journal
1. Ph.D. in the field of Immunology and Inflammation
2. Extensive experience in isolation, culture, and characterization of cell lines and human primary cells
3. Hands-on experience with common immunological assays (cell activation, proliferation assays, cytokine analysis by FACS and ELISA, and multiplex assays)
4. Experience with immune cell activation and characterization assays, multi-parameter flow cytometry, ELISA, ELISpot, RT-PCR, RNA preparation, viral transduction, mammalian cell transfection, immunoprecipitation, and western blotting.
5. Experience in the field of immunology/inflammation is required. Experience in autoimmune and/or inflammatory diseases including inflammatory bowel disease, rheumatoid arthritis, spondyloarthropathies, and/or fibrotic disease is preferable.
Note: Postdocs will be eligible for Celgene benefits but will not be entitled to receive Celgene equity, bonuses or annual merit increases. Minimum relocation assistance will be offered on a case by case basis only.
Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.