招聘简介:
令人兴奋的博士后培训机会在芝加哥大学开发新型流感疫苗
我们正在寻找一个博士后研究员来开发和测试新的通用流感疫苗候选人。
这个比尔和梅林达盖茨基金会资助的职位将涉及B淋巴细胞和流感抗体反应的研究，以开发新的通用流行性感冒病毒亚单位疫苗候选者。一种真正通用的流感疫苗接种策略必须控制病毒的逃逸突变，以及抗体对不同保护性和耐用性的表位和表位的反应演变。该疫苗旨在通过选择免疫原性和保护性抗原表位的抗体，以及远离免疫原性但不具有保护性的抗原表位，从而提高对流感多个保守、保护性抗原表位的反应，从而减少病毒逃逸。我们将使用一组独特而强大的观察、实验和计算设计来开发这种候选疫苗。总的来说，这个项目将涉及三个研究所的四个小组的合作，包括芝加哥大学的帕特里克·威尔逊和莎拉·科比小组，西奈山伊坎医学院的弗洛里安·克拉默实验室，以及弗雷德·哈钦森癌症中心的杰西·布鲁姆实验室。
英文原文:
Exciting postdoctoral training opportunity developing novel influenza vaccines at the University of Chicago
We are seeking a Postdoctoral Fellow to develop and test novel universal influenza vaccine candidates.
This Bill and Melinda Gates Foundation-funded position will involve studies of B lymphocyte and antibody responses to influenza for development of novel universal influenza vaccine candidates. A truly universal vaccination strategy against influenza must manage escape mutations by the virus and the evolution of antibody responses to and away from epitopes that differ in their protectiveness and durability. The proposed vaccine aims to minimize viral escape by boosting responses to multiple conserved, protective epitopes on influenza by selecting for antibodies to epitopes that are immunogenic and protective, and away from epitopes that are immunogenic but not protective. We will develop this candidate vaccine using a unique and powerful set of observations, experiment, and computational design. The over-all project will involve the collaborative efforts of four groups at three institutes, including: the groups of Patrick Wilson and Sarah Cobey at the University of Chicago, Florian Krammer’s laboratory at the Icahn School of Medicine at Mount Sinai, and Jesse Bloom’s laboratory at the Fred Hutchinson Cancer Center.
The position with will involve use of technologies such as flow cytometry, single-cell transcriptomics (i.e., 10x Genomics technology), plus generation and characterization of human monoclonal antibodies and ultimately production and testing of novel influenza vaccine candidates.
Candidates should have completed a doctorate level degree and have a strong background in vaccinology and/or immunology, preferably related to B cells and antibodies. The successful candidate should have documented success in research including publications in international journals on relevant topics. Compensation is dependent upon qualifications. The University provides a generous package of fringe benefits.
Applicants should submit an application package that includes a cover letter, CV, relevant prior publications, and contact information for three references to Patrick Wilson, at wilsonp@uchicago.edu.
Application review will begin immediately and continue until the position is filled.
Patrick C. Wilson. PhD
Professor of Medicine/ Section of Rheumatology
The Committee on Immunology
The University of Chicago
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