招聘简介：
纽约哥伦比亚大学欧文医学中心肾脏科的西蒙·桑娜·切尔奇博士的实验室里有一位博士后研究科学家或博士后研究员职位。
实验室
Sanna Cherchi实验室致力于了解肾病的遗传基础，特别强调先天性肾、尿路畸形和原发性肾小球肾炎。
在过去的12年中，桑纳·切尔奇博士在全球20多个国家建立了一个研究者网络，招募患者进行基因研究。他的工作涉及整个基因组学研究领域。为了补充人类特征的测序方法，他开发了新的小鼠先天性尿路缺陷模型，并使用斑马鱼模型来解剖与发育缺陷相关的结构变体内的基因。实验室的新场所涉及人类基因组学与单细胞和单核转录组学的结合，以及由携带肾病突变的患者产生的ipscs。他的研究为儿童肾脏疾病和神经发育表型（包括自闭症、智力障碍、精神分裂症等）之间提供了强有力的基因联系，并在肾脏学领域之外产生了重要影响。
他的研究成果发表在最著名的期刊上，包括《新英格兰医学杂志》（20132017）、《自然遗传学杂志》（2018）、《临床研究杂志》（2015、2018）、《美国人类遗传学杂志》（2007、2012、2015、2017）、《美国肾脏学会杂志》（2005、2009、2014）、《肾脏内科学杂志》（Kidney Internatio）。NAL（2011年、2015年）和许多其他。http://www.ncbi.nlm.nih.gov/pubmed/？术语=sanna cherchi+s）。
Sanna Cherchi博士资金雄厚，有来自美国国立卫生研究院、国防部和其他机构的多项资助；此外，他还为他的受训者提供了强有力的履历记录（美国大学妇女协会、AAW奖学金、KNWAUT MuelEN Grand；荷兰肾脏基金会博士后奖学金）；肾脏学研究会；美国肾脏学学会博士后研究会；NIDDK F和T补助金）。实验室里的受训者得到了非常有竞争力的薪水。
位置
我们正在寻找一位雄心勃勃、充满热情和动力的研究人员，在高度动态的环境中接受培训，接触人类遗传学、计算基因组学、发育生物学和干细胞研究领域的世界知名研究人员。该候选人将研究具有广泛医学相关性的儿科肾病的人类遗传学，通过使用最新的最先进的基因组工具来识别对表型有重大影响的罕见变异，并将基因组方法与单细胞分析以及干细胞生物学和发育遗传学相结合。候选人将有自己的项目，并有机会与实验室的其他研究人员合作，研究大规模基因组数据和脊椎动物功能建模。
英文原文：
A Postdoctoral Research Scientist or Postdoctoral Research Fellow position is available in the laboratory of Dr. Simone Sanna-Cherchi in the Division of Nephrology at Columbia University Irving Medical Center, New York, New York.
The Laboratory
The Sanna-Cherchi lab is focused on understanding the genetic basis of kidney disease, with special emphasis on congenital malformation of the kidney and urinary tract and primary glomerulonephritis.
During the past 12 years Dr. Sanna-Cherchi established a network of investigators across more than 20 countries worldwide recruiting patients for genetic studies. His work spans the entire spectrum of genomics research. To complement his sequencing approaches for human traits, he has developed new mouse models for congenital defects of the urinary tract, and he is using zebrafish modeling to dissect genes within structural variants associated with developmental defects. New venues in the lab involve the integration of human genomics with use of single cell and single nucleus transcriptomics and development of iPSCs from patients carrying mutations causal for kidney disease. His work provided a strong genetic link between pediatric kidney diseases and neurodevelopmental phenotypes, including autism, intellectual disability, schizophrenia, and others, with important repercussions beyond the field of nephrology.
His work has been published in the most prestigious journals, including the New England Journal of Medicine (2013,2017), Nature Genetics (2018), the Journal of Clinical Investigation (2015, 2018), the American Journal of Human Genetics (2007, 2012, 2015, 2017), the Journal of the American society of Nephrology (2005, 2009, 2014), Kidney International (2011, 2015) and many others. http://www.ncbi.nlm.nih.gov/pubmed/?term=sanna-cherchi+s ).
Dr. Sanna-Cherchi is well funded, with multiple grants from the National Institute of Health, the Department of Defense and others; moreover, he has a strong track record for securing funding for his trainees (American Association of University Women, AAUW Fellowship; KNAW Ter Muelen Grant; Dutch Kidney Foundation Postdoctoral Fellowship; Italian Society of Nephrology Fellowship; American Society of Nephrology Postdoctoral Fellowship; NIDDK F and T grants). Trainees in the lab receive a very competitive salary.
The Position
We are looking for an ambitious, enthusiastic and motivated researcher to train in a highly dynamic environment with exposure to world-renowned investigators in the field of human genetics, computational genomics, developmental biology, and stem cells research. The candidate will work on human genetics of pediatric kidney disease of broad medical relevance, by using novel state-of-the-art genomic tools to identify rare variants with large effect on the phenotype and integrate genomic approaches with single cell analyses as well as stem cell biology and developmental genetics. The candidate will have his or her own project and will have the opportunity to collaborate with other investigators in the lab working on large-scale genomic data and on functional modeling in vertebrates.
Desired Qualifications
The desired qualifications for the position are: 1) a M.D. or Ph.D. degree (preferably in Genomics, Molecular Genetics, Statistics, Bioinformatics, Computer Science, Physics, or a related field), and significant experience with large-scale genomic studies; 2) solid skills in at least one programming language (python, perl, R or C/C++); 3) practical experience in large-scale bioinformatics data analysis with familiarity with both microarray and next-generation sequencing data; 4) experience with human-derived pluripotent stem cells; 5) excellent oral and written communication skills; 6) high enthusiasm, a strong work ethic and a willingness to push the envelope.
Please email a curriculum vitae and contact information for three references to: Dr. Simone Sanna-Cherchi, Columbia University Irving Medical Center, Department of Medicine, Division of Nephrology, New York, NY 10032, email: ss2517@cumc.columbia.edu
Columbia University is an Equal Opportunity/Affirmative Action employer —Race/Gender/Disability/Veteran.
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