我们正在寻找具有高度积极性的人才，他们将享受实现独特科学的过程，并有强烈的野心来创造未来神经回路研究的趋势。佛罗里达州朱庇特的MPFI是德国着名的马克斯普朗克协会成立的第一所研究所。在欧洲之外。 MPFI的研究重点是神经回路的结构和功能，即大脑的复杂突触网络。 MPFI已经举办了许多令人兴奋的研讨会，由世界着名的研究人员提供，并与同一校园内的斯克里普斯佛罗里达学院和佛罗里达大西洋大学建立了密切的关系。能够感受到美国马克斯普朗克的精神是我们学院的另一个优势。
A postdoctoral position is available working in the laboratory of Hiroki Taniguchi Ph.D., a research group leader at the Max Planck Florida Institute (MPFI). Our research focus is on understanding development and plasticity of inhibitory interneuron subtypes (see below).
We are looking for highly motivated individuals who will enjoy the process to achieve a unique science and have a strong ambition to create trends of neural circuit research in the future.The MPFI in Jupiter, Florida is the first institute established by Germany’s prestigious Max Planck Society outside of Europe. The research focus of the MPFI is structure and function of neural circuits, the complex synaptic networks of the brain. The MPFI has had a lot of exciting seminars presented by worldrenowned researchers, and a close relationship with the Scripps Florida Institute and Florida Atlantic University on the same campus. To be able to feel Max Planck spirits in US is another advantage in our institute.
Cortical inhibitory interneurons (INs) display diverse subtypes, which innervate distinct compartments (e.g., dendrites, somata, and axon initial segments) of excitatory principal neurons (PNs) and regulate various types of circuit operations.
We have been interested in elucidating subtype-specific IN development and plasticity. To address these questions, we employ mouse genetics, molecular biology, virology, and imaging techniques. We are working on following projects.
1) Molecular mechanisms underlying specification and circuit formation of chandelier cells (ChCs), which powerfully control action potential generation in PNs by innervating their axon initial segments. We have already identified several candidate genes that are preferentially expressed in ChCs. We are analyzing the function of these genes in vivo. We have also begun to be interested in the chromatin dynamics during cell type specification.
2) We have developed a novel genetic strategy, which enables us to label and manipulate IN subtypes sending inputs to PN subtypes. We will determine the spatial organization and function of IN subtypes in cortical microcircuits. We will also elucidate mechanisms underlying the organization of IN subtypes innervating area- and layer-specific PNs.
3) The role and molecular mechanisms of structural plasticity in cortical interneurons.
Taniguchi et al.,Neuron, 2011
Taniguchi et al.,Science, 2013
Taniguchi et al.,Front. Cell. Neurosci, 2014
Ishino et al., Journal of Neuroscie, 2017
Steinecke et al., eNeuro, 2017
Yetman et al., Nature Neuroscience, 2019
Max Planck Florida Institute, Jupiter, Florida, USA. Jupiter is located in south Florida and surrounded by a lot of nature. There are many good school districts within the area. It is warm throughout the year. It must be good for family.
Applicants must have or be expected to receive a Ph.D. Experience in in vivo imaging, molecular biology, chromatin biology, and in utero electroporation is preferred but not necessary.
(Salary and benefits)
In accordance with MPFI regulations
(Start of employment)
In early 2019 (negotiable but ASAP)
(Application and required documents)
1. Complete CV including a publication list, experimental skills and contact information on 3 reference persons
2. Description of current and previous research summary (1-2 page)
3. Description of the reason why you apply and what you want to do (1-2 page)
A PDF should be sent to Hiroki Taniguchi, Ph.D. via e-mail.
Contact prior to application is welcome.