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美国NIH博士后职位

时间:2019-04-23来源:中国博士人才网 作者:佚名

招聘简介:

  卫生与公众服务部

  国家卫生研究院(NIH)

  国家癌症研究所(NCI)

  癌症治疗与诊断司

  影响新型抗癌药物的发展

  特工在国家癌症研究所接受训练

  职位描述:

  NCI癌症治疗和诊断部门正在邀请有资格的申请者担任发展治疗领域的博士后研究职位。成功的申请人将在一个多学科项目中承担主要的科学部分,该项目旨在调查活性氧(ROS)在正常和病理改变组织中的作用,以及由NADPH氧化酶(NOXS)和双氧化酶2(Duox2)介导的异常信号在炎症和肿瘤疾病中的作用。作为这项高度合作努力的重要组成部分,博士后研究人员将在与NCI癌症研究中心高级临床前研究中心(CAPR)密切互动和指导下开展其工作的重要部分;CAPR中的科学家是开发和使用各种组织的专家。f基因工程疾病模型,以了解疾病的机制。博士后研究员将重点关注的具体项目包括了解细胞氧化损伤在胃肠道炎症和癌变的开始/进展中的作用。

  在完成该项目的过程中,该博士后研究员将有机会接触并接受多种最先进的实验资源和技术的培训,如通过各种组织学/组织化学程序分析临床前组织标本,开发基因工程小鼠模型。ELS适用于适用疾病(如胰腺癌和结直肠癌),处理患者来源的异种移植模型,应用小动物成像工具监测疾病进展和治疗反应,以及广泛收集用于分子和遗传分析的其他工具。这位科学家还将致力于优化现有的体内疾病模型,以期随后将其应用于信息化的临床前药物开发。他/她还将能够获得多个研究资源和科学核心设施,以推进该项目,预计将通过同行评审期刊上的一份或多份高影响力出版物完成这项研究。这项任命将涉及到大量的多学科互动,需要在几个合作伙伴和科学支助核心之间经常协调努力。

  英文原文:

   Department of Health and Human Services (HHS)

  National Institutes of Health (NIH)

  National Cancer Institute (NCI)

  Division of Cancer Treatment and Diagnosis (DCTD)

  MAKE AN IMPACT ON THE DEVELOPMENT OF NOVEL ANTICANCER

  AGENTS COME TRAIN AT THE NATIONAL CANCER INSTITUTE

  Position Description:

  Division of Cancer Treatment and Diagnosis, NCI is inviting qualified applications for a postdoctoral research position in the area of developmental therapeutics. The successful applicant will assume a major scientific part in a multidisciplinary project aimed at investigating the role of reactive oxygen species (ROS) generation in normal and pathologically altered tissues, and the role of aberrant signaling mediated by NADPH oxidases (NOXs) and dual oxidase 2 (Duox2) in inflammatory and oncologic diseases. As an essential part of this highly collaborative effort, the postdoctoral researcher will conduct a significant part of his/her work in close interaction with, and under a guidance of, the Center for Advanced Preclinical Research (CAPR) of the Center for Cancer Research, NCI; scientists in CAPR are experts in developing and employing a variety of genetically engineered disease models to understand mechanisms of disease. The specific project that the postdoctoral fellow will focus on involves understanding the role of cellular oxidative damage in the initiation/progression of gastrointestinal inflammation and carcinogenesis.

  In the course of completing the proposed project, this postdoctoral researcher will have an opportunity to access and receive training in multiple state-of-the-art experimental resources and technologies, such as analyzing pre-clinical tissue specimens by various histology/histochemistry procedures, development of genetically engineered murine models for applicable diseases (e.g. pancreatic and colorectal cancer), handling patient-derived xenograft models, applying small animal imaging tools to monitor disease progression and therapeutic responses, as well as a broad collection of other tools for molecular and genetic analyses. This scientist will also work on optimizing the available disease in vivo models with a goal of subsequently applying them for informative preclinical drug development. He/she will also be able to access multiple research resources and scientific core facilities to advance the project and is anticipated to complete this study with one or more high-impact publications in peer review journals. This appointment will involve a substantial level of multi-disciplinary interaction and will require frequent coordination of efforts among several collaborating partners and scientific support cores.

  Qualifications:

  Ideal candidates will have a PhD degree in biochemistry, molecular/tumor biology, or related disciplines and preferably prior experience in developing of genetically and biologically engineered disease animal models for basic and translational research. Communication skills and the ability to collect, analyze, compile and communicate complex scientific data both verbally and in writing is an essential prerequisite for this position. Salary is commensurate with research experience and accomplishments.

  To Apply:

  Please send an application with resume/CV and support documentation to: Monika Sarna, administrative officer, Office of the Director, Division of Cancer Treatment and Diagnosis, Room 3A44, Building 31, 31 Center Drive, National Cancer Institute, NIH, Bethesda, MD 20892; msarna@mail.nih.gov

  This position is subject to a background investigation

  The NIH is dedicated to building a diverse community in its training and employment programs.

  DHHS, NIH AND NCI ARE EQUAL OPPORTUNITY EMPLOYERS

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