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美国加洲斯克里普斯研究所博士后职位

时间:2019-04-23来源:中国博士人才网 作者:佚名

 招聘简介:

  在美国加利福尼亚拉荷亚斯克里普斯研究所的Encarada实验室,可以获得一个博士后职位,该职位涉及神经变性、衰老和细胞内转运。我们的实验室有兴趣描述神经元中分子运动驱动转运的调节机制,缺陷转运在神经变性和衰老中的作用,以及涉及朊病毒疾病、阿尔茨海默病、转甲状腺素淀粉样蛋白和tauopathie的错误折叠蛋白的传播机制。我们还研究了神经退行性变中液-液相分离的形成机制,包括我们为各种疾病生成的神经元模型。通过将细胞生物学、遗传学、生物化学和高分辨率定量光和电镜的结合应用于各种模型系统(包括哺乳动物神经元、小鼠和线虫)的研究,您将有机会在斯克里普斯研究所的一流知识环境中进行研究。

  斯克里普斯研究所位于美丽的加州拉荷亚,是世界上最大的、私营的、非营利的研究机构之一,站在基础生物医学和转化科学的前沿。该研究所提供世界一流的资源和合作、协作的环境,促进了这里的杰出发现。

  英文原文:

  A postdoctoral position is available in the Encalada Laboratory at The Scripps Research Institute in La Jolla, California, USA, in the areas of neurodegeneration, aging, and intracellular transport. Our lab is interested in characterizing the mechanisms of regulation of molecular motor-driven transport in neurons, the role that defective transport plays in neurodegeneration and aging, and the mechanisms of spreading of misfolded proteins involved in prion diseases, Alzheimer’s disease, transthyretin amyloidoses, and tauopathies. We also investigate the mechanisms of formation of liquid-liquid phase separations in neurodegeneration including in neuronal models that we have generated for various diseases. You will have the opportunity to do research in a superb intellectual setting at Scripps Research, by applying a combination of cell biology, genetics, biochemistry, and high-resolution quantitative light and EM microscopy to your research in various model systems including mammalian neurons, mice, and C. elegans.

  The Scripps Research Institute is located in beautiful La Jolla, California, and is one of the world’s largest, private, non-profit research organizations that stands at the forefront of basic biomedical and translational science. The institute provides world-class resources and a cooperative, collaborative environment, which promotes the outstanding discoveries made here.

  REQUIREMENTS:

  1.    You are about to complete your PhD or have completed your PhD within the last year in cell biology, genetics, neurobiology, molecular biology, biophysics, or related field.

  2.    Highly motivated, independent, with outstanding written and oral communication skills, and with peer-reviewed publications.

  3.    Research experience with cell biology and light or super-resolution microscopy is highly desirable.

  Interested candidates please send a CV with a list of publications, a brief statement of your previous research expertise, your postdoctoral research interests, and the contact information of three referees to Sandra Encalada at encalada@scripps.edu. For more information also please consult our website at http://www.scripps.edu/encalada/encalada/HOME.html

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