您的位置:中国博士人才网 > 博士后招收 > 海外博士后招收 > 英国The Francis Crick Institute博士后职位

关注微信

英国The Francis Crick Institute博士后职位

时间:2019-05-08来源:中国博士人才网 作者:佚名

招聘简介:

  职位:博士后培训研究员

  地点:伦敦米德兰路弗朗西斯·克里克学院

  合同:固定期限,4年

  充分的时间

  工资:与福利竞争,取决于技能和经验

  空缺ID:10708

  总结

  在世界级的Francis Crick研究所,在由Charles Swanton教授领导的癌症进化和基因组不稳定实验室,我们正在寻找一位雄心勃勃、积极进取的湿实验室科学家,他有用老鼠模型模拟癌症的背景。这一博士后职位将由Francis Crick研究所、ERC和NC3RS资助。该职位将涉及研究基因工程小鼠模型中的肿瘤演变、癌症免疫反应和耐药性发展。这项工作将基于正在癌症进化和基因组不稳定实验室进行的tracerx研究的结果,并将涉及最前沿的研究和技术,如成像大规模细胞术和单细胞测序。候选人应具有癌症生物学和遗传学方面的深厚背景,具有良好的沟通和组织能力,并在相关领域获得博士学位(或处于完成的最后阶段)。

  英文原文:

   Job title: Postdoctoral Training Fellow

  Location: The Francis Crick Institute, Midland Road, London

  Contract: Fixed-term, 4 years

  Full time

  Salary: Competitive with benefits, subject to skills and experience

  Vacancy ID: 10708

  Summary

  At the world class Francis Crick Institute, in the Cancer Evolution and Genome Instability Laboratory headed by Professor Charles Swanton, we are looking for an ambitious, highly motivated wet-lab scientist with a background in modelling cancer using mouse models. This post-doctoral position will be funded by the Francis Crick Institute, the ERC, and the NC3Rs. The position will involve studying tumour evolution, cancer immune responses and resistance development in genetically engineered mouse models. This work will be based on findings from the TRACERx study that is ongoing in the Cancer Evolution and Genome Instability laboratory, and will involve cutting edge research and techniques such as imaging mass cytometry and single cell sequencing. The candidate should have a strong background in cancer biology and genetics, have good communication and organizational skills, and a PhD in a relevant area (or be at the final stages of completion).

  For more information please visit: https://www.crick.ac.uk/research/labs/charles-swanton.

  Project scope

  Lung cancer is the leading cause of cancer related deaths worldwide and fewer than 20% of all patients with lung cancer are alive 5 years after diagnosis. To improve patient outcomes, we need high-quality models to develop new treatment strategies. Although genetically engineered mouse models (GEMMs) have led to important findings in the past, current GEMMs do not fully recapitulate the heterogeneity observed in human tumours and consequently are not ideal for modelilng resistance development or the immune response to cancer.

  Advances in sequencing technology have facilitated in-depth genomic studies of tumour evolution. Exome sequencing on spatially separated samples demonstrated the full extent of intratumour heterogeneity in many cancer types. A study in the Cancer Evolution and Genome Instability Laboratory, Tracking Non-Small-Cell Lung Cancer Evolution through Therapy (TRACERx), aims to enrol 842 patients, from whom samples are obtained for high-depth, multiregion whole-exome sequencing of spatially separated tumour biopsies.

  In these patients, APOBEC mutation signatures were dominant in 15% of patients, and the number of subclonal mutations significantly correlated with APOBEC signatures. Ongoing chromosomal instability (CIN) was found as a second underlying cause of intratumoural heterogeneity, and was linked to poor outcome in the TRACERx dataset. It was also discovered that human HLA loss of heterozygosity (LOH) occurs in 40% of early stage non-small cell lung cancers (NSCLCs), suggesting that HLA LOH may represent an important immune escape mechanism. We aim to model these events alone and in combination, to generate tractable animal tumour evolution models to study clone fitness, immune evasion and the role of subclonal driver events.

  Postdoctoral Training Fellows are expected to lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and guide PhD students in their research. The ability to work in a team is essential.

  About us

  The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

  An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

  The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

  The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

  ·         If you are interested in applying for this role, please apply via our website.

  ·         The closing date for applications is 28 May 2019 at 23:30.

  ·         All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

  Key words

  Please complete this section with key words and terms that people may enter into a search engine when they are job hunting. This will help us to make your advert more visible to the target market, for example:

  Example

  ·         Cancer biology

  ·         Mammalian development

  ·         Mouse genetics

  ·         Flow Cytometry

  ·         Image Mass Cytometry

  ·         Single Cell Sequencing

  ·         Lung Cancer

  ·         Immunology

为防止简历投递丢失请抄送一份至:boshijob@126.com(邮件标题格式:应聘职位名称+姓名+学历+专业+中国博士人才网)

中国-博士人才网发布

声明提示:凡本网注明“来源:XXX”的文/图等稿件,本网转载出于传递更多信息及方便产业探讨之目的,并不意味着本站赞同其观点或证实其内容的真实性,文章内容仅供参考。