英国牛津大学招聘免疫学、单细胞转录组学、单细胞数据分析等相关领域博士后科学家

This exciting new role has arisen as a result of a new collaborative research project aimed at studying the earliest events of inflammation induced by vaccine adjuvants in human lymphoid

tissue from different ethnic backgrounds. The project will be carried out in close partnership with Prof. Mark Coles (The Kennedy Institute of Rheumatology, Oxford) and Dr Calliope Dendrou (The Wellcome Centre for Human Genetics, Oxford). The project is funded by the CZI and is linked to the Human Cell Atlas.

We are seeking an exceptional, enthusiastic and motivated Postdoctoral Scientist with a passion for novel scientific approaches and technological advances. The successful applicant will work primarily within the Vaccine Formulation Group at the Jenner Institute, under the supervision of Dr Anita Milicic, with access to Prof. Coles’ and Dr Dendrou’s laboratories.

The project focuses on a novel ex vivo model of controlled adjuvant-induced inflammation in human lymph nodes (LNs). To map the earliest events and spatio-temporal progression of inflammation this model system will be combined with single-cell resolution technologies. The tissue will be exposed to conventional (aluminium salt) and novel (AS01-like) adjuvants, and the inflammatory response followed through time within the tissue. LNs will be obtained from individuals of European, Asian, and African ethnic background, and the cell types, activation states and trajectories driving inflammation will be characterised by agnostic (10x) and inflammatory gene-specific (BD Rhapsody) single-cell RNA-seq methods. In parallel, the spatial organisation of the inflammatory response dynamics will be mapped at the protein level by hyperplexed imaging (GE CellDIVE).

Informal enquires about the post are welcome. Please contact anita.milicic@ndm.ox.ac.uk

Responsibilities

•Design and perform original research using human lymphoid tissue

•Contribute to single-cell transcriptomics data analysis

•Adapt existing and develop new scientific techniques and experimental protocols.

•Maintain awareness of the relevant literature.

•Work independently, testing hypotheses and analysing scientific data, reviewing and refining working hypotheses as appropriate.

•Manage own academic research and administrative activities. This involves small scale project management, to co-ordinate multiple aspects of work to meet deadlines.

•Collaborate in the preparation of scientific reports and journal articles and occasionally present papers and posters.

•Regularly communicate with Dr Anita Milicic, Dr Dendrou and Prof. Coles, and other members of the groups as required, ensuring that they are kept fully up to date with progress and any difficulties in the research project.

•To be responsible for overseeing the daily housekeeping of the laboratory area and performing any other comparable duties as may be required to ensure the efficient running of the laboratory.

•Attend appropriate scientific seminars, training opportunities and meetings in the Institute and University.

•To be responsible with others for the biological safety of the laboratory.

•Assist in dissemination of findings of the research group by authorship of manuscripts, presentation of results at meetings, and contribution to the group website.

•Participate in and support the public engagement and widening access activities of the Department and the University. This is anticipated to be not more than 2 days per year.

•Undertake mandatory training as required by the University, Division and Department. The specific list of training courses may change from time-to-time, in response to both legal and internal University requirements.

Once trained the post holder’s performance will be continually monitored to ensure that the required standard of accuracy and efficiency is maintained.

All employees will have to ensure that their work in the laboratory is conducted safely at all times and, in particular, that work is undertaken following the appropriate health and safety policies and procedures for the particular area, without compromise to their own safety or that of others who may be affected.

Pre-employment screening

All offers of employment are made subject to standard pre-employment screening, as applicable to the post.

If you are offered the post, you will be asked to provide proof of your right-to-work, your identity, and we will contact the referees you have nominated. You will also be asked to complete a health declaration (so that you can tell us about any health conditions or disabilities so that we can discuss appropriate adjustments with you), and a declaration of any unspent criminal convictions.

We advise all applicants to read the candidate notes on the University’s pre-employment screening procedures, found at: www.ox.ac.uk/about/jobs/preemploymentscreening/.

Hazard-specific / Safety-critical duties

This job includes hazards or safety-critical activities. If you are offered the post, you will be asked to complete a health questionnaire which will be assessed by our Occupational Health Service (OHS), and the offer of employment will be subject a successful outcome of this assessment.

The hazards or safety-critical duties involved are as follows:

•Lone Working

•Working with category 3b or 4 lasers (laser safety class)

•Working with infectious pathogens (hazard group 2)

•Working with blood, human products and human tissues

•Work in clinical areas with direct contact with patients (NOT administrative roles)

•Work with allergens, Eg laboratory animals, pollen, dust, fish or insects etc

•. Work with any substance which has any of the following pictograms on their MSDS:

•Travel outside of Europe or North America on University Business.

Additional security pre-employment checks

This job includes duties that will require additional security pre-employment checks:

•A satisfactory basic Disclosure and Barring Service check due to working with human tissue and access to certain pathogens or toxins

•University security screening (eg. identity checks)

Selection criteria

Essential selection criteria

•PhD (or near to completion) in the field of immunology

•Experience with tissue handling techniques (human lymph nodes in particular)

•Proven experience in at least two of the following techniques: human tissue dissociation

and cellular profiling, single-cell transcriptomics, single-cell data analysis,

confocal/hyperplexed imaging

•Ability to drive a project to completion as evidenced by at least one first author peer reviewed paper and a good publication record, commensurate with experience

•Proven ability to interpret scientific data, analyse and research complex issues and write research

reports

•High level of precision and demonstrable attention to detail

•Proven organisational and interpersonal skills to collaborate with other researchers within

and outside of the Institute

•Clear and effective communication skills

Desirable selection criteria

•Proficiency with a high-level programming language (eg. C++, Java, Python) and/or appropriate scripting languages

•Proficiency with statistical data analysis tools such as R

•Ability to write manuscripts for peer review and publication

•Experience in supervising junior staff/students

About the University of Oxford

Welcome to the University of Oxford. We aim to lead the world in research and education for the benefit of society both in the UK and globally. Oxford’s researchers engage with academic, commercial and cultural partners across the world to stimulate high-quality research and enable innovation through a broad range of social, policy and economic impacts.

We believe our strengths lie both in empowering individuals and teams to address fundamental questions of global significance, while providing all our staff with a welcoming and inclusive workplace that enables everyone to develop and do their best work. Recognising that diversity is our strength, vital for innovation and creativity, we aspire to build a truly diverse community which values and respects every individual’s unique contribution.

While we have long traditions of scholarship, we are also forward-looking, creative and cutting-edge. Oxford is one of Europe’s most entrepreneurial universities. Income from external research contracts in 2016/17 exceeded £564m and we rank first in the UK for university spin-outs, with more than 130 companies created to date. We are also recognised as leaders in support for social enterprise.

Join us and you will find a unique, democratic and international community, a great range of staff benefits and access to a vibrant array of cultural activities in the beautiful city of Oxford.

For more information, please visit www.ox.ac.uk/about/organisation.

Medical Sciences

The Medical Sciences Division is an internationally recognized centre of excellence for biomedical and clinical research and teaching. We are the largest academic division in the University of Oxford

World-leading programmes, housed in state-of-the-art facilities, cover the full range of scientific endeavour from the molecule to the population. With our NHS partners we also foster the highest possible standards in patient care.

For more information please visit: www.medsci.ox.ac.uk

Nuffield Department of Clinical Medicine (NDM)…fostering your career in science

The Nuffield Department of Clinical Medicine (NDM) is one of the largest departments of the University of Oxford and is part of the Medical Sciences Division, with responsibility for a significant part of the teaching of clinical students within the Medical School.

NDM has significant financial turnover and complexity, resulting from its diverse research portfolio, its geographical spread and its close links with NHS funding and strategic teams involved in the development and delivery of increasingly integrated clinical research platforms. For more information please visit: http://www.ndm.ox.ac.uk/home

The Nuffield Department of Clinical Medicine has been presented with a Departmental Athena SWAN Silver award in recognition of the commitment made to promote gender equality through our organisational and cultural practices and our efforts to improve the working environment for both men and women. For more information please see our Departmental Athena SWAN pages: www.ndm.ox.ac.uk/working-for-ndm/aboutndmatheneswan/ .

The Jenner Institute

The Jenner Institute was founded in November 2005 to develop innovative vaccines against major global diseases. Uniquely it focuses both on diseases of humans and livestock and tests new vaccine approaches in parallel in different species. A major theme is translational research involving the rapid early-stage development and assessment of new vaccines in clinical trials.

For more information please visit: department website http://www.jenner.ac.uk/

How to apply

Before submitting an application, you may find it helpful to read the ‘Tips on applying for a job at the University of Oxford’ document, at www.ox.ac.uk/about/jobs/supportandtechnical/.

If you would like to apply, click on the Apply Now button on the ‘Job Details’ page and follow the on-screen instructions to register as a new user or log-in if you have applied previously. Please provide details of two referees and indicate whether we can contact them now.

You will also be asked to upload a CV and a supporting statement. The supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. This may include experience gained in employment, education, or during career breaks (such as time out to care for dependants).

Your application will be judged solely on the basis of how you demonstrate that you meet the selection criteria stated in the job description.

Please upload all documents as PDF files with your name and the document type in the filename.

All applications must be received by midday on the closing date stated in the online advertisement.

Information for priority candidates

A priority candidate is a University employee who is seeking redeployment because they have been advised that they are at risk of redundancy, or on grounds of ill-health/disability. Priority candidates are issued with a redeployment letter by their employing department(s).

If you are a priority candidate, please ensure that you attach your redeployment letter to your application (or email it to the contact address on the advert if the application form used for the vacancy does not allow attachments).

Should you experience any difficulties using the online application system, please email recruitment.support@admin.ox.ac.uk. Further help and support is available from www.ox.ac.uk/about_the_university/jobs/support/. To return to the online application at any stage, please go to: www.recruit.ox.ac.uk.

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