Post-Doctoral Position in Pharmacogenomics for Glioma - SN1220
Luxembourg Institute of Health
Description
Our Jobs
Post-doctoral position in pharmacogenomics for glioma - SN1220
Post-doctoral position in pharmacogenomics for glioma - SN1220
To be part of the NORLUX Neuro-Oncology Laboratory (Group leaders: Prof Simone Niclou and Dr. Anna Golebiewska within the Department of Oncology at the LIH, we are currently looking for a Postdoctoral Fellow.
84, rue Val Fleuri, Luxembourg L-1526, Luxembourg
05/01/2021 11:07:15
Background. Diffuse gliomas are the most frequent and most dismal primary brain tumours in adults. Gliomas undergo cellular and molecular evolution during disease progression, which is only partially explained by genetic evolution, suggesting that transcriptional and epigenetic changes may be the basis of cellular adaptation processes. The international GLASS (Glioma Longitudinal AnalySiS) initiative, aims to systematically catalogue the temporal changes in gliomas at the genetic, epigenetic and transcriptomic levels. In this context, NORLUX aims to assess differential functional drug responses of primary versus recurrent gliomas.
Objectives. By combining mulitomics molecular characterisation and high content drug screens on ex vivo patient-derived glioma organoids from paired longitudinal tumors, we aim to determine differences in drug sensitivity and predict personalized treatment options for recurrent glioma patients. Patient- derived orthotopic xenografts (PDOX) will be applied for in vivo validation studies.
Training and research environment. The NORLUX lab is a dynamic, multinational and interdisciplinary team focusing on the biology of malignant brain cancer. It is part of the Department of Oncology and uses cutting edge technologies, including genomic, metabolomic and proteomic analyses, single cell technologies (single cell RNA-Seq, CYTOF, Imagestream) as well as state-of-the-art preclinical models. The project will be performed in collaboration with the international GLASS consortium (www. glass- consortium.org/). The post-doctoral fellow will be supported through a FNR CORE funded project and will join an interdisciplinary project team, including cellular and molecular biologists, animal experts, bioinformaticians and statisticians. Recent related reference: https: // pubmed.ncbi.nlm.nih.gov/33009951/
KEY SKILLS, EXPERIENCE AND QUALIFICATIONS
PhD in Molecular Biology or Biomedical Sciences with experience in cancer research.
Experience in molecular biology and genome-wide molecular profiling is required. Previous experience in drug screening, epigenetics (ATAC-seq), multi-omics analyses and imaging is desirable.
Animal experimentation diploma (FELASA or equivalent) will be an asset.
Independent and self-motivated person, scientific creativity and originality, strong team spirit and collaborative capacity, excellent time management, rigor, perseverance, strong writing skills.
Fluency in English is mandatory.
Researchers are supported by easy access to scientific expertise, well- equipped facilities, an active seminar program as well as opportunities for conference attendance and collaborations with other research organisations.
REF.: CM/PDPG1220/SN/Norlux3-year fixed-term contract, full time. Start date: April 2021scientific contact
Prof Simone Niclou, PhD
84 Val Fleuri
L-1526 Luxembourg
LUXEMBOURG
simone.niclou@lih.lu
More information about the group can be found here : https: // norlux.lih.lu
为防止简历投递丢失请抄送一份至：boshijob@126.com（邮件标题格式：应聘职位名称+姓名+学历+专业+中国博士人才网）
中国-博士人才网发布
声明提示：凡本网注明“来源：XXX”的文/图等稿件，本网转载出于传递更多信息及方便产业探讨之目的，并不意味着本站赞同其观点或证实其内容的真实性，文章内容仅供参考。
