Research Fellow in Protein Chemistry for Targeted Drug DeliveryUniversity of Leeds
Description
Working closely with a second research fellow in the School of Physics & Astronomy, you will join a multidisciplinary team based in the Schools of Chemistry, Physics & Astronomy, Medicine and Electronic Engineering (Prof Bruce Turnbull, Prof Steve Evans, Dr Zhan Ong, Dr Jon Sandoe and Prof Steve Freear) to work on an EPSRC funded project to develop the use of microbubbles for targeting and treatment of microbial biofilm infections.
Antibiotics are becoming less effective because of resistance developed by bacteria. We aim to combat antibiotic resistance by developing better antibiotics as well as improving the way we use existing ones. In this project we will use microbubbles, similar to those already used as ultrasound scanning contrast agents, to deliver antibiotics directly to a site of infection. You will develop methods to conjugate the bubbles to proteins that target bacterial biofilms and assess their molecular targeting activity in microfluidic systems under flow conditions. You will investigate if combinations of molecular targeting proteins improve biofilm targeting. You will also perform experiments to load liposomes with antimicrobial peptides, and attach them to the microbubbles. You will perform drug release studies to investigate if the combined use of targeted microbubbles and ultrasound drug release methods can provide enhanced antibiotic efficiency.
To explore the post further or for any queries you may have, please contact:
Professor Bruce Turnbull
Tel: +44 (0)113 343 7438
Email: w.b.turnbull@leeds.ac.uk
为防止简历投递丢失请抄送一份至：boshijob@126.com（邮件标题格式：应聘职位名称+姓名+学历+专业+中国博士人才网）
中国-博士人才网发布
声明提示：凡本网注明“来源：XXX”的文/图等稿件，本网转载出于传递更多信息及方便产业探讨之目的，并不意味着本站赞同其观点或证实其内容的真实性，文章内容仅供参考。
