Postdoc in bacteriology with focus on development of rapid antimicrobial susceptibility testing
Postdoc in bacteriology with focus on development of rapid antimicrobial
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The positions will be atProf. Zhen Zhang's group in the Solid-State Electronics division, the Department of Electrical Engineering.The multidisciplinary postdoc project will be in close collaboration with Prof. SannaKoskiniemi at the Department of Cell and Molecular Biology, Uppsala Biomedical Centre, Uppsala University.
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Project description Rapid antibiotic susceptibility tests (rASTs) are highly desired in modern clinical practice for quick selection of right antibiotics to treat infectious diseases at the early but critical stage. However, currently available testing methods normally require growth of bacteria into colonies, which usually take more than two days to accomplish a task. They are, therefore, not satisfactory for practical needs that require fast answers. Moreover, these methods are not applicable for slow-growing bacteria, or samples containing sub-populations of slow- or non-growing bacteria which can resume growth after the antibiotic attack. To understand if and how the sub- population of slow-/non-growing bacteria causes failure in infection treatments, rASTs at the single cell level is required. To address these challenges, our project aims at developing a novel Silicon (Si) chip based all-electrical testing platform to achieve rAST at single cell level. The success of this project will potentially provide a low-cost and rapid ASTs platform for effective infection treatments. It could also help to accelerate the development of new antibiotic drugs in the pharmaceutical industry.
Duties The applicant is expected to drive the bacteriological side of the project. Duties include general microbiology and molecular biology work in the laboratory as well as experimental work in the clean room facility with testing the devices being developed. Bioinformatic analyses of bacterial genomes to identify metabolic pathways are included. The project requires extensive knowledge about bacterial metabolism and physiology, so the duties include literature searches as well as oral presentations and writing/editing of scientific papers.
Requirements PhD degree in microbiology, molecular biology or similar or a foreign degree equivalent to a PhD degree.
The degree needs to be obtained by the time of the decision of employment. Those who have obtained a PhD degree three years prior to the application deadline are primarily considered for the employment. The starting point of the three-year frame period is the application deadline. Due to special circumstances, the degree may have been obtained earlier. The three-year period can be extended due to circumstances such as sick leave, parental leave, duties in labour unions, etc.
The candidate is expected to be able to work independently and to have a strong interest in antibiotic resistance, tolerance and bacterial metabolism. In addition, the candidate is expected to take own initiatives as well as to collaborate with colleagues both within and outside of the research group. The position is in an international context so good oral and written communication skills in English are essential. Finally, significant weight will be given to personal suitability such as; analytical and organizational skills, personal maturity, ability to work with others, take initiatives, and to show good judgement.
Additional qualifications Documented ability of work relating to bacterial metabolism is meriting
About the employment The employment is a temporary position of 2 years according to central collective agreement. Scope of employment 100 %. Starting date as agreed. Placement: Uppsala
For further information about the position, please contact: Professor Zhen Zhang, telephone +46 18-471 3131, firstname.lastname@example.org and associate professor SannaKoskiniemi, telephone: +46 70 7607616, email: email@example.com
Please submit your application by 15th of March, 2023, UFV-PA 2023/568.
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Placement: Department of Electrical Engineering
Type of employment: Full time , Temporary position
Pay: Fixed salary
Number of positions: 1
Working hours: 100%
County: Uppsala län
Union representative: SekoUniversitetsklubben firstname.lastname@example.org ST/TCO email@example.com Saco-rådet firstname.lastname@example.org
Number of reference: UFV-PA 2023/568
Last application date: 2023-03-15