The successful candidate will work on comprehensive projects studying the pathogenesis and metabolic consequences of prion infection. The candidate's focus will be divided evenly amongst investigating the metabolic consequences of prion infection, elucidating the role of prion strains in the efficient transmissibility of certain prion agents, and the influence of the route of inoculation on the genesis of unique prion strains. The project will include rodent model systems, in situ prion detection assays, and in vitro amplification systems.
The prion diseases are fatal, progressive neurodegenerative disorders characterized by the accumulation of a misfolded isoform (PrPD) of the cellular prion protein (PrPC). These prion diseases include Creutzfeldt-Jakob disease (CJD), variant CJD (vCJD), bovine spongiform encephalopathy (BSE), scrapie, and chronic wasting disease (CWD). Our laboratory investigates the in vivo consequences of prion infection, including mechanisms of neurodegeneration, pathways of prion trafficking and shedding, determinants of prion infectivity, and the influence of prion strains on prion infectivity and clinical disease.
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