Technical University of Denmark (DTU)
2800 Kgs. Lyngby, Denmark
We seek an open-minded Postdoc with broad experience in developing and testing drug delivery strategies for brain diseases. Drug delivery to the brain remains a tremendous challenge for treating the diseases that develop in an aging population. The drugs that have the potential to limit the consequences of these diseases are characterized by a large size, and therefore, with no capacity for transporting across the blood-brain barrier. Many strategies to transport these large molecules into the brain have been tested, but at this point, no successful strategies have shown clinical benefits for the patients. In this project, we intend to develop nanomedicine strategies to bind the blood-brain barrier and transport neuroactive drugs into the brain tissue.
The research is within design and production of varying types of targeted nanoparticles. In this case, the nanoparticles are functionalized with different peptides or proteins that are able to bind to receptors expressed on the luminal surface of the blood-brain barrier. There is a strong focus both on state-of-the-art high-sensitivity quantification techniques, as well as morphological and functional assessment of the nanoparticle transport. The research is cross-disciplinary and involves interaction with researchers having expertise in synthetic chemistry, nanoparticle formulation, and in vitro/in vivo assessment of nanoparticle behavior.
Responsibilities and tasks
We seek a candidate that has a broad background in nanoparticle production and testing in in vivo systems. A strong background in neuroanatomy and neuromalignant diseases is also preferred. The research will be to create novel strategies for transporting nanoparticles into the brain. We aim to validate the system both in vitro and in vivo, and we intend to introduce animal models at a very early timepoint. Based on your interests and network, other types drug delivery strategies may be employed as well.
You will be responsible for testing novel brain drug delivery systems in large-scale in vivo studies, as well as making mechanistic studies in vitro, and explore the limits and possibilities of these brain drug delivery systems in the treatment of diseases, e.g. brain cancer. Depending on the candidate profile, it is also possible to be involved designing and producing the drug delivery systems in collaboration with synthetic chemists and formulation specialists.
You will have the opportunity to guide Master students and to teach at practical courses.
The project will mostly be done at DTU Nanotech in the group of Thomas L. Andresen. Since the project is a part of the Lundbeck Foundation Research Initiative on Brain Barriers and Drug Delivery, collaborative projects with participants from other Danish universities. We encourage the postdoc to reach out to these collaborators to improve the resulting research.
Candidates should have a PhD degree or equivalent.
As the field is cross disciplinary, we may accept candidates from many fields but preferably the candidate has a PhD in the field on brain drug delivery, where the PhD project included usage or development nanomedicines. FELASA-accredited certificate in Laboratory Animal Science is a requirement.
You must be highly motivated for developing new drug delivery strategies for treating severe neurological diseases.
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.
Salary and terms of employment
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. The period of employment is 3 years.
You can read more about career paths at DTU here.Further information
Further information may be obtained from Thomas L. Andresen, firstname.lastname@example.org.
You can read more about the Department of Micro- and Nanotechnology at www.nanotech.dtu.dk.
Please submit your online application no later than 15 October 2018 (local time). Apply online at www.career.dtu.dk.
Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply online", fill out the online application form, and attach all your materials in English in one PDF file. The file must include:
· Application (cover letter)
· Diploma (MSc/PhD)
· List of publications
Applications and enclosures received after the deadline will not be considered.
All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply.
DTU Nanotech - the Department of Micro- and Nanotechnology - is situated in the northern part of Copenhagen. DTU Nanotech is a centre of excellence in micro- and nanotechnology utilising sciences across the traditional boundaries of technology, thereby enabling innovative solutions for the benefit of society. DTU Nanotech has approx. 270 staff members. With 40 % international employees, the department constitutes an international environment.
DTU is a technical university providing internationally leading research, education, innovation and scientific advice. Our staff of 6,000 advance science and technology to create innovative solutions that meet the demands of society, and our 11,200 students are being educated to address the technological challenges of the future. DTU is an independent academic university collaborating globally with business, industry, government and public agencies.