Postdoctoral Researcher : Minneapolis, MN, United States

DNA Replication & Repair/Basic Cancer Research at the University of Minnesota, Twin Cities

A postdoctoral position is available for NIH-funded projects that will investigate the functional interactions between DNA replication machinery and DNA repair pathways for genome stability and tumor suppression using mouse models. In particular, the Shima Lab is interested in elucidating the role of dormant replication origins in the recovery of stalled replication forks. For more information, please see our papers listed below.

Kawabata et al., (2011) Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression. Mol Cell 41:543-553.
-Previewed in Mol Cell 41:495-496 (2011).

Kawabata et al., (2011) A reduction of licensed origins reveals strain-specific replication dynamics in mice. Mamm Genome 22: 506-517.

Shima et al., (2007) A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice, Nature Genetics 39: 93-98.
- Previewed in Nat Genet 39:10-11 (2007) and Nature Review Cancer 7:6-7 (2007).

We are looking for a highly motivated individual with a recent PhD or MD/PhD. A candidate must have a strong background in molecular biology/genetics and is expected to work at the bench independently.

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