Why Mayo Clinic
Highly motivated postdoctoral scientists are invited to join the Translational Neuro-Oncology Laboratory of Jann Sarkaria (http://www.mayo.edu/research/labs/translational-neuro-oncology) to develop novel therapeutic strategies for the treatment of glioblastoma (GBM). Global interests in the lab include understanding the basis of resistance to chemotherapy and radiation, identifying methods to overcome therapy resistance, defining how heterogeneous drug delivery across the blood-brain barrier impacts cellular response to therapy, and integration of novel signal transduction and DNA repair inhibitors into chemo-radiotherapy for treatment of GBM. Many of these studies are supported by an extensive collaborative network that is NIH funded as the MIT/Mayo Physical Sciences Center for Drug Distribution and Drug Efficacy in Brain Tumors (http://psoc.mit.edu/). There is a heavy emphasis on in vivo studies that are supported by an extensive collection of patient-derived xenografts (PDX) developed from GBM and brain metastasis resection specimens. The PDX models are highly characterized at a phenotypic and genomic level with histology, growth kinetics, whole-exome sequencing and RNA sequencing, respectively, and are widely distributed throughout the Neuro-oncology research community as an NINDS-funded National Resource (http://www.mayo.edu/research/labs/translational-neuro-oncology/mayo-clinic-brain-tumor-patient-derived-xenograft-national-resource). Human tissue studies are supported by an extensive human tumor biobank available within the Mayo Clinic Neuro-Oncology program. The laboratory is integrated within the larger Mayo Clinic Neuro-Oncology Program and the Alliance for Clinical Trials in Oncology to facilitate translation of novel findings into clinical trials for GBM patients. The ultimate goal for the laboratory is to define curative treatment strategies for this currently incurable and devastating disease.
A Research Fellow at Mayo Clinic is a temporary position intended to provide training and education in research. Individuals will train in the research program of a Mayo Clinic principal investigator. Qualified individuals will demonstrate the potential for research as evidenced by their training and peer-reviewed publications and should become competitive for national research grants. Proof of English proficiency is required for J-1 Short-Term Scholars, Research Scholars, Professors, Specialists, and Student Interns sponsored by Mayo Clinic. 800146; J2WRTP
Must have a Ph.D., M.D., or equivalent doctoral degree in a field deemed relevant by the program. Research Fellow is appropriate for individuals who have completed no more than one prior postdoctoral fellowship, at Mayo Clinic or elsewhere. Please attach the following required documents at the time of application:
Current curriculum vitae and bibliography
Three letters of recommendation, signed, on letterhead, describing:
Relationship to the applicant.
Past work/academic performance.
Work qualities/personal conduct.
Overall assessment of potential for success in research environment.
Doctoral degree certification, if applicable:
Original or notarized copy of diploma or final transcript issued by school (English translation required).
Mayo Clinic is located in the heart of downtown Rochester, Minnesota, a vibrant, friendly city that provides a highly livable environment for more than 34,000 Mayo staff and students. The city is consistently ranked among the best places to live in the United States because of its affordable cost of living, healthy lifestyle, excellent school systems and exceptionally high quality of life.
Postdoc & Temporary Research
Post Doctoral Research
Radiation Oncology, Research
Job posting number
Equal opportunity employer
Mayo Clinic is an equal opportunity educator and employer (including veterans and persons with disabilities).