Apply in vitro evolution to generate large-scale molecular diversity using the bacterial periplasmic binding protein (PBP) structure as the fundamental science level
* Understand the binding mechanisms of the new PBPs and pave the way for the design of biosensors for a much broader range of analytes in future projects
* Join CSIRO, Australia's leading scientific research organisation
It is widely accepted that increased adoption of sensing technologies will transform many industries over the next 50 years. Biosensors will play an important part in this transformation. The Fellow will apply in vitro evolution to generate large-scale molecular diversity using the bacterial PBP structure as the transduction scaffold which is fully compatible with CSIRO's proprietary Cybertongue device. The Fellow will have access to CSIRO's supercomputer clusters, state-of-the-art molecular modelling software packages and world class C3 protein crystallography facilities.
Specifically you will:
- Develop PBPs with specificities to a number of structurally related nitrogen-based heterocyclic compounds using in vitro evolution
- Develop and screen a diverse 'structure-guided' library of synthetic PBP sequences
- Characterise the binding specificities and signalling characteristics of selected PBPs, define non-selected effects of the introduced amino acid substitutions
- Participate in the identification of further opportunities arising from research and initiate new lines of research
- Assist in the planning and preparation of research proposals, carry out investigations requiring originality, creativity and innovation
- Present results at international conferences, publish in scientific journals for the highest possible impact
Location: Canberra, Australia
Salary: $81k - $88k plus up to 15,4% super
Term: 3 years
Reference Number: ACT13/03727
To be successful, you will have:
- A PhD, or will shortly satisfy the requirements for a PhD in a relevant scientific discipline, and no more than 3 years relevant post doctoral experience
- Ability to conduct innovative research in protein design, expression and biochemical characterisation
- Strong oral and written communication skills including the ability to publish results in scientific journals
- Ability to develop experimental plans and pursue novel research approaches
- Proven originality, creativity and innovation in problem solving and introducing new directions or approaches
- Ability to work with a broad range of people and independently, to meet performance deadlines
- Experience with biophysical analysis of proteins, in silico protein modelling or experience with biosensing and biosensors is desirable
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