Helmholtz Zentrum München
Job Title: Postdoctoral scientist m/f in a research project to phenotypically and epigenetically analyse the effects of parentally acquired diabetes on the proge
Job Number: 4014783 (Ref.#. 2014-2453)
Date Posted: 08/20/2014
Application Deadline: Open Until Filled
Job Description
The Helmholtz Zentrum München in Munich, Germany, is member of one of the leading research associations in Europe - the Helmholtz Association of German Research Centers. The aim of our research is to proactively detect health risks involving humans and the environment, decoding the mechanisms of pathogenesis and developing concepts for prevention and therapy.
The Institute of Experimental Genetics is looking for a Postdoctoral scientist (m/f) in a research project to phenotypically and epigenetically analyse the effects of parentally acquired diabetes on the progeny in an animal model 2014/2453
Job Description
A major goal in this project within the framework of the French-German Diabetes Academy is to begin to dissect
the contribution of epigenetic inheritance versus the effect of the maternal environment to the predisposition of deve-loping a diabetic phenotype in the offspring.
• Use of an established mouse model for acquired diabetes
• Phenotypic analyses of progeny from diabetic mothers, in particular, with
regards to classical diabetes parameters
• Molecular analyses (including metabolomics, proteomics and
transcriptomics)
of selected organs
• Analyses of maternal effects on the epigenome of the progeny (DNA
methylation, histone modifications and chromatin accessibility)
Your Qualifications
• Candidates are highly motivated scientists with a degree in biology,
molecular biology, biotechnology, biochemistry, or in a similar faculty and
have an excellent doctorate
• Previous knowledge in molecular and/or genetic methods, in particular in
next generation sequencing, in metabolic disorders, as well as experience
or interest in working with mouse models will be to your advantage
• Above-average commitment and the ability to work in a team, as well as
analytic thinking, independent working, very good computer skills,
knowledge of statistical methods and excellent knowledge of written and
spoken English are necessary prerequisites
Our Offer
• Working in an innovative, well- equipped and scientifi-cally stimulating
surrounding
• Perform research in an internationally leading and highly attractive
academic environment
• Perform independent research in an interdisciplinary team with exceptional
facilities for phenotyping, muta-genesis, transcriptomics, proteomics and
metabolomics and within international cooperations.
• Further training opportunities
• Initial short-term employment contract for two years with a standard public
service salary (TV EntgO Bund EG 13)
The Helmholtz Zentrum München as holder of the Bavarian Advancement of Women Prize and of the Total E-Quality Certificate is striving to increase the overall proportion of women on its staff and thus expressly urges qualified women to apply.
Theresa Schwarzfischer
E-mail: t.schwarzfischer@helmholtz-muenchen.de
Helmholtz Zentrum München
Deutsches Forschungszentrum für Gesundheit
und Umwelt (GmbH)
Institute for Biological and Medical Imaging
Ingolstädter Landstr. 1
D-85764 Neuherberg/München, Germany
Contact: Theresa Schwarzfischer
Institute for Biological and Medical Imaging
Helmholtz Zentrum München
Ingolstädter Landstr. 1
Neuherberg-München, 85764
Germany
Email: t.schwarzfischer@helmholtz-muenchen.de
Employer's Web Site: Visit employer's website
亥姆霍兹慕尼黑中心
职位名称：在一个研究项目，博士后科学家，男/女，以表型和表观遗传学分析肠胃后天糖尿病对PROGE的影响
发布日期：二○一四年八月二十〇日
报名截止日期：不限满为止
职位描述
亥姆霍兹慕尼黑中心位于德国慕尼黑，是全球领先的研究团体在欧洲的一个成员 - 德国研究中心的亥姆霍兹联合会。我们研究的目的是要主动地检测涉及人类和环境的，解码发病机制和开发的概念对于预防和治疗的健康风险。
实验遗传学研究所正在寻找一个博士后科学家（男/女）的一个研究项目，表型和表观遗传学分析在动物模型二千四百五十三分之二千〇十四肠胃收购合并糖尿病对后代的影响
职位描述
在法国，德国糖尿病学会的框架内该项目的主要目标是，开始解剖
表观遗传与母体环境对的倾向影响的贡献德韦-loping的后代糖尿病的表型。
•利用已建立的小鼠模型获得的糖尿病
•表型分析从糖尿病母亲的后代，尤其是与
关于古典糖尿病参数
•分子分析（包括代谢组学，蛋白质组学和
转录）
选择器官
•对后代的表观基因组母体效应分析（DNA
甲基化，组蛋白修饰和染色质可访问）
你的资历
•考生都非常积极的科学家，主修生物学，
分子生物学，生物技术，生物化学，或者类似的教师和
有一个很好的博士学位
•先前知识在分子和/或遗传方法，特别是在
下一代测序，在代谢性疾病，以及经验
或与小鼠模型的工作权益将是你的优势
•高于平均水平的承诺，并在一个团队中工作，以及能力
分析思考，独立工作，很不错的电脑技能，
统计方法的知识和优秀的书面知识，
英语口语是必要的先决条件
我们的报价
•工作中的一个创新，装备精良和scientifi，刺激美云
周边
•在国际上处于领先和极具吸引力进行研究
学术环境
•在一个跨学科的团队，卓越的执行自主研发
为表型，墓塔，成因，转录组学，蛋白质组学和设施
代谢组学和国际合作范围内。
•进一步培训的机会
两年•初始的短期雇佣合同与标准的公共
服务人员薪金（电视EntgO外滩EG13）
亥姆霍兹慕尼黑中心的总电子质量认证的巴伐利亚提高妇女奖和持有人正在努力增加妇女在其工作人员的整体比例，从而明确敦促合格的妇女申请。
特里萨Schwarzfischer
电子邮箱：t.schwarzfischer@helmholtz-muenchen.de
亥姆霍兹慕尼黑中心
德意志FORSCHUNGSZENTRUM献给Gesundheit
UND UMWELT（有限公司）
研究所生物和医学成像
IngolstädterLandstr。 1
D-85764 Neuherberg市/慕尼黑，德国
联系方式：特里萨Schwarzfischer
研究所生物和医学成像
亥姆霍兹慕尼黑中心
IngolstädterLandstr。 1
Neuherberg市 - 慕尼黑，85764
德国
电子邮件：t.schwarzfischer@helmholtz-muenchen.de
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