Postdoctoral Training Fellow in Intestinal Tissue Engineering : London, United Kingdom
This is a full-time, fixed term position for 4 years on Crick Terms and Conditions of Employment.
Salary competitive plus benefits, subject to skills and experience
The Francis Crick Institute (the Crick) is a partnership between the Medical Research Council (MRC), Cancer Research UK (CRUK), the Wellcome Trust, University College London (UCL), Imperial College London and King’s College London. It is a registered charity whose purpose is to conduct biomedical research into all aspects of human health and disease.
The institute will be a world-leading centre of biomedical research and innovation. It will promote connections between researchers and disciplines and between academic institutions, healthcare organisations and businesses. Dedicated to research excellence, the institute will have the scale, vision and expertise to tackle the most challenging scientific questions underpinning health and disease. It will be world-class with a strong national role — training scientists and developing ideas for public good. On 1 April 2015, staff from the London Research Institute (CRUK) and National Institute for Medical Research (MRC) transferred to the Crick to form a fully functional research institute on four sites. In 2016, the Crick will move to a single new, purpose-built research centre in St. Pancras which will house some 1,500 staff.
We seek a talented and motivated postdoc in the area of intestinal tissue engineering to join Dr. Vivian Li’s laboratory.
Organisation
Dr Li’s laboratory focuses on understanding the mechanisms of intestinal stem cell lineage specification and tumourigenesis. The ultimate goal is to translate the basic stem cell research to the clinic to aid cancer treatment and regenerative medicine.
Research techniques used in the laboratory include: molecular biology, biochemistry, 3-D human and mouse intestinal organoid culture, genome editing, confocal imaging, tissue engineering, mouse genetics and histopathology.
Objectives
The research aim is to engineer functional intestinal grafts for orthotropic transplantation. In this project, some of the specific aims could include but not limited to:
3-D organoid culture derived from primary human and mouse intestine
Decellularisation of intestine
Co-culture of myofibroblasts, endothelial cells, neural crest cells etc.
Recellularisation using bioreactor
Animal handling including surgery (e.g. kidney capsule transplantation)
Liaise with external collaborators both in the UK and abroad and visit collaborators’ labs to perform shared experiments
Write and contribute to the preparation of scientific manuscripts, reports, presentations and records of experimental plans and results
Supervise and provide technical advice to more junior members of the team when appropriate
Person Specification
The post holder should embody and demonstrate our core Crick values: Bold, Imaginative, Open, Dynamic and Collegial, in addition to the following:
Essential
PhD in Developmental Biology, Stem Cells, Molecular Biology or similar (or in the final stages of PhD submission)
Good knowledge and experience in molecular biology and tissue engineering
Technical expertise in cell and tissue culture
Proven track record of research (i.e. publication record)
Strong written and oral communication skills
Ability to work independently and also capable of interacting within a group
Ability to design experiments, report on research progress and outcomes openly and review methodologies in response to feedback
Desirable
Experience in 3-D organoid culture
Experience in the use of bioreactor for tissue engineering
Experience in animal handling and surgery (including kidney capsule transplantation)
Experience in histology and microscopy
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