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美国菲尼克斯翻译基因组学研究院转化质谱方向博士后

时间:2016-12-29来源:未知 作者:91boshi

Post Doc Fellowship - Collaborative Center for Translational MassSpectrometry
Employer:  TGen
Job Number:  4019407
Date Posted:  12/22/2016

Job Description

Elucidate phosphosignaling networks in medulloblastoma in a highly engaging post-doctoral fellowship position at the Collaborative Center for Translational MassSpectrometry.

Duties and Responsibilities:

Dr. Patrick Pirrotte, Assistant Professor and Director of the Collaborative Center for Translational Mass Spectrometry (TGen) is currently seeking to hire a Postdoctoral Research Scholar. This position involves design, execution, and supervision of technical personnel conducting experiments on the proteomics and biochemistry (signal transduction pathways, primarily phosphosignaling) underlying the invasive behavior of pediatric brain tumors, with a specific focus on medulloblastoma. The Postdoctoral Scholar will be fully embedded in a highly prolific, multi-institutional collaboration with partners in California and Europe. He/She will collaborate with other Scholars at TGen and foster relations with researchers in medulloblastoma and neuroblastoma. He/She will work closely with Dr. Pirrotte on peer-reviewed and new projects that involve co-investigators within TGen and at outside institutions. The Scholar will assume progressively more autonomous responsibilities for project development and execution with the aim of career maturation towards being an independent (extramurally-funded) scientist. The Fellow will assist in manuscript preparation, grant proposal development, and progress reports.

Projects in the laboratory include cancer-centric investigations that require competency, proficiency, and/or familiarity with (the majority of) the following,

Mission critical requirements in experimental Design, technical execution, data analysis, interpretation, and presentation of findings:

1) proteomics using mass spectrometry, phospho-PTM discovery, signal pathway analysis, protein-protein interactions; 
2) cancer-related in vitro cell biology studies of mammalian cell proliferation, apoptosis, migration, and viability; 
3) protein biochemistry using western blot, immunoprecipitation, densitometry, immunofluorescence, immunohistochemistry, confocal microscopy, upright epifluorescence microscopy.

Education and Preferred Qualifications:
- Ph.D. (completed or near completion) in Molecular Biology or related field is desired.
- Prior research experience or training in the field of cancer biology is preferred.
- Background in cancer and experience in phosphoproteomics is preferred.
- Proven track record of creativity and established track record of publishing in peer-reviewed journals.
- Excellent written and verbal communication skills.

Nice-to-have requirements:
1) molecular biology techniques including DNA sequencing, qRT-PCR, cell & tissue processing for isolation of DNA, RNA, and protein, plasmid design and construction, siRNA and transfection experiments;
2) Experimental Design, technical execution, data analysis, interpretation, and presentation of findings from datamining of gene expression profiling, SNP frequencies, aneuploidy measurements.

About TGen
The Translational Genomics Research Institute (TGen) is a preeminent leader in precision medicine, translating genetic and genomic discoveries with life changing results. We are defining 21st century health care delivery with major advances in genomic-enabled medicine that are revolutionizing how to prevent, diagnose and treat diseases. TGen specializes in helping patients with cancer, neurodegenerative disorders, infectious disease, metabolic diseases, and rare childhood disease. Our translational research enterprise provides an unparalleled environment for innovation, discovery and creative collaboration supported by physicians and scientists who are prominent leaders in their fields.

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