Job title: Senior Laboratory Research Scientist – Cryo-electron Microscopy Scientist *
*Location: The Francis Crick Institute, Midland Road, London
Contract:Fixed-term (3 years), full time
Salary: Competitive with benefits, subject to skills and experience
Vacancy ID: 8364
Short summary
The Francis Crick Institute seeks to recruit a Cryo-electron Microscopy (cryo-EM) Scientist to support single-particle and tomography projects. The research scientist will be appointed to the Structural Biology Science Technology Platform (SB STP), which supports the Crick in the areas of protein science (expression and purification), biophysics, X-ray crystallography, cryo-EM and related areas. The post-holder will build on existing strengths at the Crick Institute in cryo-EM by interacting with the Crick Coordinator for Science and Innovation in Cryomicroscopy (CSIC), research groups in cryo-EM, other structural biology laboratories and members of the technology platform. There are excellent opportunities for career advancement.
The Crick has a state-of-the-art facility for cryo-electron microscopy and computation and the post will consolidate excellence in these areas. The STP currently houses two Titan Krios 300kV microscopes each equipped with a Volta phase plate and Falcon III detector (one has an additional Gatan energy filter and K2 detector) and these are complemented by a Talos Arctica 200kV microscope and a 120kV Spirit TEMscreening microscope. There are excellent facilities for computing and expertise in experimental and computational aspects of cryo-EM being developed through the structural biology platform with support from the Crick Scientific Computing STP.
Description
The successful candidates key responsibilities will be (but are not limited to):
• Support a range of cryo-EM research activities through interaction with Crick scientists including cryo-EM scientists and other structural biologists interested in cryo-EM.
• Contribute to management and maintenance of high-end cryo-electron microscopes
• Support experimental design including sample preparation and imaging of biological specimens.
• Provide expertise and support in computational image analysis.
• Provide training in both experimental and computational aspects of cryo-EM.
About us
The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.
An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.
The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.
The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.
• If you are interested in applying for this role, please apply via our website.
• The closing date for applications is 30 September 2018 at 23:30.
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.
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