Two postdoctoral positions are available in the laboratory of Dr. Xiaolu Yang at the Perelman School of Medicine at the University of Pennsylvania. The lab studies neurodegenerative diseases and cancer. Current projects focus on two areas:
(1) Protein quality control and the pathogenesis of neurodegenerative diseases. Our lab recently identified a novel protein quality control system in animal cells that is multifunctional and powerful. We are investigating the mechanism of action of this system and its role in aging and neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, ALS, and polyglutamine diseases.
(2) The tumor suppressor p53 and tumor cell metabolism. We are interested in the functions and regulation of preeminent tumor suppressor p53. Our recent results revealed an important role for p53 in modulating metabolism. We are continuing to investigate the function of p53 as both a sentinel and a regulator for various metabolic activities. We are also studying metabolic alterations that drive tumor initiation and progression.
For more information on the laboratory and its research, please see the following publications and website:
Nature Communications 9(1): 1223, 2018
Nature Communications 9(1): 4683, 2018
Cell Reports 18(13): 3143-3154, 2017
Molecular Cell 55: 15-30, 2014 (cover article)
Nature 493: 689-93, 2013
Nature Cell Biology 15: 991-1000, 2013 (cover article)
Nature Cell Biology 13: 310-6, 2011 (cover article)
Molecular Cell 37: 668-78, 2010 (cover article)
Cell 133: 415-26, 2008
Molecular Cell, 31: 415-21, 2008
Successful candidates should have an expected or recently earned Ph.D. degree, a strong record of scientific productivity, and extensive experience in a related field, including but not limited to molecular biology, biochemistry, cell biology, cancer, metabolism, neuroscience, and cell/mouse models of neurodegenerative diseases.
To apply, please send a cover letter, curriculum vitae, and the names and addresses of three references to:
Xiaolu Yang, PhD
Professor, Department of Cancer Biology
Investigator, Abramson Family Cancer Research Institute
Member, Penn Medicine Neuroscience Center
Perelman School of Medicine
University of Pennsylvania
654 BRB 2/3, 421 Curie Blvd
Philadelphia, PA 19104-6160