招聘简介：
位于密苏里州圣路易斯的华盛顿大学医学院的克里斯托弗·斯特金博士的实验室里有一个博士后职位。我们已经开发出新的人类多能干细胞定向分化策略，可以产生胚胎外和胚胎内的造血祖细胞。有几个研究项目可供选择，都集中在这些hpsc衍生的造血干/祖细胞的翻译潜能。可能的项目包括从hpsc衍生的过继免疫疗法的发展，造血发展的表观遗传和转录后调控，以及可移植造血人群的特征。
申请人将负责管理自己的项目，并在鲟鱼实验室内以及与其他当地团体进行合作。申请人应具有博士或医学博士学位，并具有相关研究经验和出版记录。良好的英语口头和书面沟通能力是必不可少的。在造血/免疫学、发育生物学或细胞生物学方面有很强背景者优先，但不需要。以前的生物信息学或小鼠异种移植试验将是一种资产。
英文原文：
A postdoctoral position is available in the laboratory of Dr. Christopher Sturgeon, at the Washington University School of Medicine, in St. Louis, MO. We have developed novel human pluripotent stem cell (hPSC) directed differentiation strategies that generate extra-embryonic and intra-embryonic like hematopoietic progenitors. Several research projects are available, all focused on the translational potential of these hPSC-derived hematopoietic stem/progenitor cells. Possible projects range from the development of hPSC-derived adoptive immunotherapies, epigenetic and post-transcriptional regulation of hematopoietic development, and the characterization of engraftable hematopoietic populations.
The applicant will be responsible for managing their own projects as well as collaborating both within the Sturgeon laboratory, and with other local groups. Applicants should have a PhD or MD and demonstrated relevant research experience and publication record. Excellent verbal and written English communication skills are essential. A strong background in either hematopoiesis / immunology, developmental biology, or cell biology is preferred, but not required. Previous bioinformatics or murine xenograft assays would be an asset.
Interested applicants should send a current CV, statement of research interests, and 2-3 contacts for reference letters, to Christopher Sturgeon (csturgeon@wustl.edu)
Representative publications include:
1) Sturgeon CM, Ditadi A, Awong G, Kennedy M, Keller G. Wnt Signaling Controls the Specification of Definitive and Primitive Hematopoiesis From Human Pluripotent Stem Cells. Nature Biotechnology. 2014 32(6):554-561
2) Ditadi A, Sturgeon CM, Tober J, Awong G, Kennedy M, Phillips A, Ng ES, Stanley E, French DL, Cheng X, Gadue P, Speck N, Elefant AG, Keller G. Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages. Nature Cell Biology. 2015 17(5):580-591
3) Creamer JP, Dege C, Ren Q, Ho JTK, Valentine MC, Druley TE, Sturgeon CM*. Human definitive hematopoietic specification from pluripotent stem cells is regulated by mesodermal expression of CDX4. Blood. 2017 129(22):2988-2992.
4) Fok WC, Niero ELO, Dege C, Brenner KA, Sturgeon CM*, Batista LFZ*. p53 mediates failure of definitive hematopoiesis in dyskeratosis congenita. Stem Cell Reports. 2017 9(2):409-418
5) Ditadi A, Sturgeon CM, Keller G. A view of haematopoietic development from the Petri dish. Nature Reviews Molecular Cellular Biology. 2017 18(1):56-67
For more information about our lab research please visit our website (www.sturgeonlab.com).
We offer competitive salaries and benefits, please refer to the Human Resources website (http://hr.wustl.edu), and information on being a postdoc at Washington University in St. Louis can be found at http://postdoc.wustl.edu/prospective-postdocs.
Diversity and Inclusion are core values at Washington University. Washington University seeks an exceptionally qualified and diverse faculty, staff, students and postdocs; women, minorities, protected veterans, and candidates with disabilities are strongly encouraged to apply.
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