Radu博士的研究小组确定了两种独立的途径，这些途径参与了Stargardt病的发病机制，这是一种青少年形式的黄斑变性，它将视网膜色素上皮细胞（RPE）作为疾病的主要部位：（1）有毒维生素A副产物的积累从视觉循环中视紫红质再生; （2）RPE细胞中补体系统的失调。探索这些途径的交叉点是NEI R01资助支持的博士后奖学金的基础。
A postdoctoral position is available in the Retina Biochemistry & Clinical Disease Modeling Laboratory in the newly renovated, state-of-the-art research space at the Stein Eye Institute, UCLA (https://apptrkr.com/1434138). The candidate will have a strong interest in translational research that involves integrating clinical findings of retinal degeneration with basic science research. Dr. Radu’s Lab focuses on identifying and understanding the molecular mechanisms of retinal dystrophies by developing and studying disease systems (both cell- and animal-based models) utilizing cutting-edge technologies.
Dr. Radu’s group identified two independent pathways involved in the pathogenesis of Stargardt disease, a juvenile form of macular degeneration, which implicate the retinal pigment epithelium (RPE) as the major site of the disease: (1) accumulation of toxic vitamin A byproducts derived from the visual cycle for rhodopsin regeneration; and (2) dysregulation of the complement system in the RPE cells. Exploring the intersection of these pathways is the basis for this postdoctoral fellowship supported by an NEI R01 grant.
The postdoctoral candidate will be expected to design and perform the relevant functional studies using RPE cultured cells derived from human samples. The applicant will also be tasked with implementing in vivo experiments using complex-genetic animal models. We are seeking an independent and motivated individual with excellent organizational, interpersonal, and communication skills (both verbal and written).
Candidates are expected to hold a Ph.D. and/or M.D. with less than 2 years of postdoctoral experience, be self-motivated and demonstrate a record of research achievement. A strong background in mouse genetics, biochemistry, cell biology, primary cell isolation, cell transfection, cell-based assays, nucleic acid and protein manipulation, proficiency in microscopy and data analysis are necessary.
Please send a Curriculum Vitae with a complete bibliography and the names of three professional references to Principal Investigator Roxana Radu, MD at email@example.com.
The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy see: UC Nondiscrimination and Affirmative Action Policy.