立即可用于高度积极的博士，该职位的重点是使用造血干细胞（HSCs）和基因疗法治疗多系统退行性疾病，特别是神经肌肉疾病的遗传方法。该项目中使用的基因治疗技术包括慢病毒载体和CRISPR / Cas9介导的基因编辑。候选人还将在体外测定和遗传疾病的鼠模型中使用人和小鼠HSC。该项目还包括调查HSC衍生细胞拯救退行性神经肌肉组织所涉及的机制。成功的候选人将成为具有尖端仪器和设施的激动人心的合作科学环境的一部分。
Available immediately for highly motivated Ph.Ds, the position focuses on the use of hematopoietic stem cells (HSCs) and gene therapy for the treatment of inherited approaches for multi-systemic degenerative disorders, and in particular neuromuscular diseases. Gene therapy technologies employed in the project include lentivirus vectors and CRISPR/Cas9-mediated gene editing. The candidate will also use human and mouse HSCs in in vitro assays and murine models of genetic disorders. The project also includes the investigation of the mechanism involved in the rescue of degenerative neuromuscular tissues by HSC-derived cells. Successful Candidates will be part of a stimulating and collaborative scientific environment with cutting-edge instrumentation and facilities.
Qualifications Required and Preferred Academic Background
The candidate should be highly self-motivated, with strong communication and interpersonal skills and the ability to work independently, has a PhD, with a strong background in stem cell biology, gene therapy and CRISPR/Cas9-mediated gene editing and neuroscience. Experience with mice is required.
If you are interested, please submit your C.V. to Stephanie Cherqui firstname.lastname@example.org.