Postdoctoral Research Associate - Pulmonary Immunology
University of Texas Health Science Center at Tyler
Tyler, Texas; close to Dallas, TX
Negotiable, depending on experience
March 19 2020
Science Ad for Dr. Kant 2020
Life Sciences, Immunology, Microbiology, Physical Sciences, Signal Transduction, Health Sciences, AIDS/HIV, Medicine, Vaccine Research
A postdoctoral position is available at the Department of Pulmonary Immunology to study the PK/PD of the anti-tuberculosis drugs as well as immune response to M. tuberculosis infection. Applicants must have a strong background in microbiology and immunology. Prior experience of working with M. tuberculosis and small animal model is desirable. Hands-on experience in drug screening studies, DNA/RNA sequencing data analysis and multicolor flow cytometry is essential for this position. The selected candidate will use the EMA approved and FDA endorsed state-of-the-art hollow fiber model of tuberculosis, cellular and molecular imaging facility and next generation sequencing for the project. Applicants should submit their CV to Ds. Shashi Kant [firstname.lastname@example.org], The Department of Pulmonary Immunology, The University of Texas Health Northeast, 11937 US Highway 271, Tyler, TX 75708-3154.
Key publicationsfrom our research group
1.Ordonez AA, Wang H, Magombedze G et al. Dynamic imaging in patients with tuberculosis reveals heterogeneous drug exposures in pulmonary lesions. Nat Med 2020.
2.Dheda K, Lenders L, Srivastava S et al. Spatial network mapping of pulmonary multidrug-resistant tuberculosis cavities using RNA sequencing. Am J Respir Crit Care Med 2019; 200: 370-80.
3.Magombedze G, J P, Srivastava S et al. Transformation morphisms and time to extinction analysis that map therapy duration from pre-clinical models to patients with tuberculosis: translating from apples to oranges. Clin Infect Dis 2018; 67: S349-S58.
4.Srivastava S, Magombedze G, Koeuth T et al. Linezolid dose that maximizes sterilizing effect while minimizing toxicity and resistance emergence for tuberculosis. Antimicrob Agents Chemother 2017; 61: pii: AAC.00751-17.
5. Srivastava S, Deshpande D, Pasipanodya JG et al. Optimal clinical doses of faropnenem, linezolid, and moxifloxacin in children with disseminated tuberculosis: Goldilocks. Clin Infect Dis 2016; Suppl 3: S102-9.
6. Srivastava S, Pasipanodya JG, Meek C et al. Multidrug-resistant tuberculosis not due to noncompliance but to between-patient pharmacokinetic variability. J Infect Dis 2011; 204: 1951-9.
As an Equal Opportunity Employer, the University will, in accordance with State and Federal law and regulations, provide equal opportunity in all employment related activities without regard to race, color, religion, national origin, gender, age, disability, sexual preference, or status as a disabled veteran or a veteran of the Vietnam Era. The University requires pre-employment drug and tobacco screening and criminal background check on all hires. Specific job requirements or physical location of some positions allocated to this classification, may render this position security sensitive, and thereby subject to the provisions of Section 51.215, Texas Education Code.