法国国家健康与医学研究院（INSERM）2023年招聘博士后（遗传性肌肉疾病的基因组编辑）
法国国家健康与医学研究院（法文为：Institut national de la santé et de la recherche médicale），简称“Inserm”，成立于1964年，是一所总部位于法国巴黎的国家级公共科学和技术研究机构，其前身是成立于1941年的法国国家卫生研究院，由法国卫生部和研究部共同管理 [1]。Inserm是法国唯一一个完全致力于人类健康的公共研究组织 [2]，参与从研究到治疗的全过程，其宗旨通过增进对生命和疾病的知识、创新治疗方法和公共卫生研究，促进全人类健康。
Postdoctoral Researcher – Genome Editing For Inherited Muscular Disorders
Universities and Institutes of France
France
October 31, 2023
Contact:N/A
Offerd Salary:Negotiation
Location:N/A
Working address:N/A
Contract Type:Other
Working Time:Full time
Working type:N/A
Ref info:N/A
27 Aug 2023
Job Information
Organisation/Company
INSERM
Research Field
Biological sciences
Researcher Profile
Recognised Researcher (R2)
Country
France
Application Deadline
31 Oct 2023 - 23:00 (UTC)
Type of Contract
To be defined
Job Status
Full-time
Hours Per Week
To be defined
Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme
Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
A postdoctoral position is available in the therapeutic genome editing team under the direction of Dr. Mario Amendola in Genethon, biopark of Evry, France and it is funded by the Horizon Europe (https: // magic-horizon.eu/). This project deals with neuromuscular and musculoskeletal disorders, which are amongst the most frequent causes of disability in Europe. These genetic diseases are characterized by severe skeletal muscle wasting, impaired mobility, reduction of quality of life and premature death. Although supportive treatments are in clinical practice to manage symptoms, there is still no cure for muscular dystrophies. Thus, the overarching objective of our project is the generation of innovative models of human skeletal muscle disorders to develop, screen and validate new neuromuscular gene therapy vectors and genome editing strategies with high efficacy and selective tropism coupled with low toxicity and limited immunogenicity. Relevant publications below. Our laboratory focuses on: 1) developing effective and safe genome editing and gene therapy strategies for the treatment of human genetic diseases, in particular muscular disorders, hemoglobinopathies and lysosomal storage; 2) understanding of these pathologies and their molecular mechanisms; 3) understanding DNA repair and how to modulate/exploit to improve efficacy and safety of genome editing tools.
Where to apply
Website
https: // jobrxiv.org/job/inserm-27778-postdoctoral-researcher-genome-editing- for…
Contact
Website
https: // www. linkedin.com/feed/update/urn:li:activity:7100978153208061952/
STATUS: EXPIRED
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